In situ hybridization reveals the locations of LYVE-1 mRNA+ cells in lymph node medulla.
Research
Research projects led by CLI investigators span a spectrum of studies from the cells comprising the lymphatic vasculature to the genetic and clinical aspects of hereditary lymphedema. Our interests include: identification of genes that contribute to hereditary lymphedema; lymphedema resulting from sentinel node surgery to treat cancer; cancer metastasis; placental lymphatics and preeclampsia; infectious diseases including HIV/AIDS, dengue, tuberculosis, and influenza; and vaccination development and improvement.
Research Images
Differential interference contrast image of cultured human dermal lymphatic endothelial cells.
Simultaneous in situ hybridization for Prox-1 mRNA and immunohistochemistry for pdoplanin in lymph node subcapsule.
Combined in situ hybridization for LYVE-1 mRNA and immunohistochemical staining for podoplanin in lymph node medulla.
Confocal microscopic image of spleen stained for the lymphatic marker LYVE-1 (red) and macrophage marker tCD68 (green).
